Diabetes Update 2010
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As we learn more about the pathophysiology of type 2 diabetes mellitus (T2DM), the level of therapeutic complexity continues to grow. Whether this involves the approval of new medications, new insights into potential drug side effects, or changes in treatment goals, it is in the community provider’s best interest to stay abreast of the latest developments in the management of T2DM.
This article updates the participant on 7 key developments in the treatment of T2DM: 1) saxagliptin (OnglyzaTM), the new dipeptidyl-peptidase-4 (DPP-4) inhibitor, 2) research evaluating “tight” glucose control in patients with T2DM, 3) cardiovascular risk with rosiglitazone (Avandia®) and pioglitazone (Actos®), 4) safety warnings for insulin secretagogues (i.e., sulfonylureas, meglitinides), 5) the potential link between insulin glargine (Lantus®) and cancer, 6) promising new insulin formulations through the inhaled and buccal routes of administration, and 7) liraglutide, a once-daily glucagon-like peptide-1 (GLP-1) analog similar to exenatide (Byetta®). Accompanying each review is a synopsis of pertinent patient counseling information.
Publication Date: 01/01/2010
Expiration Date: 01/01/2013
CE Credit: 1.5 (0.15 CEU)
Type of Activity: Knowledge-based
This program was developed by The Rx Consultant and published by Continuing Education Network, Inc.
The Rx Consultant accepts no advertising or financial support from the pharmaceutical industry and
is funded solely by the purchase of programs. The Rx Consultant is dedicated to providing unbiased,
balanced information to health care practitioners.
Programs developed by The Rx Consultant are written by health care providers with expertise in the topic
area, peer-reviewed, extensively edited, and fact-checked. This development process was created to insure
that every program presents information that is current, accurate, relevant to "real world" health care
providers, and written in an easy reading, "plain English" style.
Joshua J. Neumiller, PharmD, CDE, CGP, FASCP, Assistant Professor, Department of Pharmacotherapy, Washington State University, and Matthew Rhea, MBA, PharmD Candidate (2010), Washington State University, Spokane, WA.
Dr. Neumiller receives grant support from Novartis, Merck, and GlaxoSmithKline. Mr. Rhea has nothing to disclose. Professor Campbell (guest editor) is on the Speaker’s Bureaus for Daiichi-Sankyo and Eli Lilly and Co.
Guest Editorial Advisor
R. Keith Campbell, RPh, MBA, CDE, FASHP
This accredited program is targeted to pharmacists and nurses.
Goals & Objectives
At the conclusion of this program, participants will be able to:
- Discuss recent developments surrounding the development and clinical use of medications for the treatment of T2DM.
- Outline important considerations and counseling points for patients currently on, or previously taking, medications such as saxagliptin (Onglyza™), thiazolidinediones, insulin secretagogues, and insulin glargine (Lantus®).
- Discuss how insulin products and incretin mimetics in the developmental pipeline have the potential to improve patient care, adherence, and treatment acceptance.
- Provide practical guidance and counseling regarding cardiovascular risk for patients taking a thiazolidinedione or receiving intensive glucose management.
The Rx Consultant is a publication of Continuing Education Network, Inc.
Continuing Education Network, Inc. is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education as a
provider of continuing pharmacy education.
Continuing Education Network is approved by the California Board of Registered Nursing, Provider Number CEP 13118. Programs approved by CA BRN are accepted by most State Boards of Nursing.
ACPE Universal Activity Number: 428-0000-10-001-H01-P
Exam & Credit Statement Procedures
Upon successful completion of this program and the post test (70%), 1.5 hours of continuing education credit will be awarded. To receive credit and your exam score, please complete the exam questions and
Editorial and Review Board
Chief Editor and CE Administrator
Terry M. Baker, PharmD
Tracy Farnen, PharmD
James Chan, PharmD, PhD
Pharmacy Quality and Outcomes Coordinator
Associate Clinical Professor
School of Pharmacy
University of California San Francisco
San Francisco, CA
Richard Ron Finley, B.S. Pharm.,R.Ph.
Clinical Pharmacist (volunteer faculty)
University of California, San Francisco (UCSF) Memory and Aging Center
Lecturer (Emeritus) UCSF, Department of Clinical Pharmacy
Health Sciences Clinical Professor, UCSF School of Pharmacy
San Francisco, CA
Ray Dolby Brain Health Center, Sutter Health/CPMC
San Francisco, CA
Consult Pharmacist Aging and Adult Health Services
San Francisco Health Department
San Francisco, CA
Julio R. Lopez, PharmD, FCSHP
Chief of Pharmacy Service
VA Northern California Health Care System
Adjunct Clinical Professor
College of Pharmacy
Assistant Clinical Professor
School of Pharmacy
University of California, San Francisco
San Francisco, CA Adjunct Professor
Thomas J. Long School of Pharmacy
University of the Pacific
Visiting Associate Professor and Lecturer
Samuel Merritt University
Pamela Mausner, MD
Helen Berlie, Pharm.D. CDE, BCACP
Clinical Assistant Professor, Pharmacy Practice
Wayne State University
Ambulatory Care Specialist - Diabetes
Health Centers Detroit Medical Group
Senior Editorial Advisor
Gerard Hatheway, PharmD, PhD
Belinda M. Danielson, RPh
Christopher M. DeSoto, PharmD
Angie S. Graham, PharmD
Cynthia Chan Huang, PharmD, MBA
Fred Plageman, PharmD
Editorial Advisor and Clinical Practice Consultant for Nurse Practitioners
Meuleman, RN, C, MS
About the Rx Consultant
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educate patients about drugs and manage drug therapy. The reader is responsible for confirming
the information presented here and interpreting it in relation to each patient's specific situation before utilizing the information.
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